Category Archives: Genetics

Best of ’23: A4M Reader’s Choice Award

A year of incredible progress, 2023 saw scientific breakthroughs abound. From revelations in epigenetic reprogramming and cellular biology to advancements in medical artificial intelligence technology, the longevity and anti-aging medicine movement forged forward at breakneck speed — and we did our best to keep pace.

So that you, valued members of our community of innovative health professionals, never missed a beat. Armed with the latest research takeaways, best practices, and breaking news, A4M Blog readers always stay ahead of the curve.

Stepping into 2024, we reflect on the monumental discoveries unlocked across the longevity landscape last year and the ones you found most captivating. We’ve gathered 2023’s most popular articles and hope you help us determine the A4M Reader’s Choice Award winner by casting your vote below! And the nominees are…

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The Genetics Behind Regeneration

Many animals are capable of regenerating complex body parts and restoring them to full functioning. Salamanders and planarians regrow damaged or missing body parts, while flatworms can replicate their entire bodies from minuscule components of themselves. The human body is comparatively limited in its ability to regenerate, as humans are only capable of renewing damaged organs such as the liver and skin. However, recent research in animal regeneration has revealed various stem cell strategies for regenerating body parts, that could one day be applied to humans.

“Scientific Breakthrough:” Editing Genes in Human Embryos

Publications have been reporting on a recent breakthrough in modern medicine: modifying human DNA in human embryos, without introducing the critically serious disease-causing mutations that were problematic in previous attempts.

Published online Wednesday in the journal Nature, the research is targeted towards assisting families with genetic diseases. The new research experiment utilized a gene-editing technique to correct a genetic defect behind a heart disorder, that can cause “seemingly healthy young people” to die from sudden heart failure. Scientists at Oregon Health and Science University, in conjunction with colleagues in California, China, and South Korea, reported that dozens of embryos were repaired: if those embryos developed, not only would they be disease-free, but also would not transmit the disease to future generations.

This is the first time that scientists have successfully edited genes in human embryos to prevent dangerous disease mutations. Scientists collectively agree that while the research is a major milestone and achievement, the prospect of human genetic engineering has already raised ethical concerns. Mary Darnovsky, director of the Center for Genetics and Society—a watchdog group based in Berkeley—says that it is “a flagrant disregard of calls for a broad societal consensus in decisions about a really momentous technology that could be used for good, but in this case is being used in preparation for an extraordinarily risky application.”

Yet the researchers emphasize that the work is focused on preventing debilitating diseases and disorders, not the creation of genetically enhanced babies. Richard Hynes, a cancer researcher at the Massachusetts Institute of Technology who co-led the committee, says that their report sought to eliminate the technical hurdles, but there will inevitably be “societal issues that have to be considered and discussions that are going to have to happen.”

While the overwhelming consensus is that much more research is required before the method could be tested through clinical trials—which is currently not permissible under federal law—the technique could potentially apply to over 10,000 conditions caused by specific inherited mutations. This includes diseases like Tay-Sachs, Huntington’s, sickle cell anemia, cystic fibrosis, and many others.

Nevertheless, any scientists hoping to continue the work in the U.S. are presented with a host of regulatory obstacles. The research was specifically funded by Oregon Health and Science University, the Institute for Basic Science in South Korea, and a number of foundations, as the National Institutes of Health does not fund any work involving human embryos. Moreover, Congress has prohibited the Food and Drug Administration to consider any research or experiments that involve genetically modified human embryos.

Scientists in Britain have received approval to use CRISPR—the gene editing technology—to edit the DNA in healthy human embryos, in order to further research surrounding normal human development; a team in Sweden has also started similar experiments. Fredrik Lanner, a geneticist at the Karolinska Institute in Stockholm—conductor of the experiments—says that this needs to be highly regulated. “This is very exciting. But it also could be a double-edged sword. So I think we really have to be extra cautious with this technology.”