Excessive Amounts of Vitamin D Linked to Kidney Damage

Used for its wide-ranging purported benefits from reducing cancer risk to maintaining healthy bones and teeth, vitamin D is readily available to the public in the form of supplements and over-the-counter formulations. Declared a global epidemic in 2010, vitamin D deficiency continues to affect billions of individuals worldwide. However, new research indicates the potential toxicity of excess amounts of vitamin D. The common perception that consuming increased amounts of the vitamin can only lead to added benefits may be wrong, as recent evidence reveals it can actually lead to increased harm on the body, specifically kidney failure.

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Chronic Inflammation and Cognitive Impairment

Chronic inflammatory diseases are the most significant cause of death across the globe and their prevalence is projected to rise persistently over the next few decades in the United States. Although inflammation occurs naturally in the body and the majority of the population will experience acute inflammation at some point in their lifetime, it may trigger the beginning of a disease process if left untreated. Tissue death and the thickening or scarring of connective tissue are just some of the detrimental outcomes related to ongoing inflammation. Prolonged or chronic inflammation can lead to long-lasting damage of the heart, brain, and other organs, increasing the risk of cardiovascular events and mortality rates.

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The Endocannabinoid System and the Modulation of Pain and Inflammation

The Endocannabinoid System

The recent discovery of the endocannabinoid system (ECS) and its modulatory role in many physiological functions has been very exciting for science. The three major constituents of the ECS include the endocannabinoid signaling molecules; mainly anandamide and 2-AG, G-protein-coupled cannabinoid receptors, and enzymes involved in ligand on-demand synthesis and inactivation.

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