Beyond Senolytics - The Emerging Era of Precision Senescence Medicine

Beyond Senolytics: The Emerging Era of Precision Senescence Medicine

Cellular Senescence and Senotherapeutics

Cellular senescence was once considered “the end” – a point where cultured somatic cells simply stopped proliferating. The recent recognition of senescence as a central mechanism underlying aging and the development of age-associated disorders has given rise to senotherapeutics, a class of therapies dedicated to targeting cellular senescence and either eliminating senescent cells or modifying their senescence-associated secretory phenotype (SASP), the pro-inflammatory factors they secrete. Because the accumulation of senescent cells contributes to tissue dysfunction, chronic inflammation, and age-related diseases, emerging anti-aging and regenerative medicine strategies are evolving into precision senescence medicine and taking aim at cellular senescence to enhance human healthspan.

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XPRIZE Healthspan Finals

XPRIZE Healthspan Finals: The Latest in the Race to Extend Healthy Aging

Imagine reaching your 70s or 80s with the strength to keep moving, the clarity to stay engaged, and the independence to continue living life on your own terms. For too many people, the later decades of life are marked not by vitality, but by impaired muscle function, cognition, and immune function.

But what if we could change what it means to grow old? As populations age and age-related conditions continue to rise worldwide, improving healthspan has become one of the defining scientific and public health challenges of our time. It’s a challenge the $101 million XPRIZE Healthspan competition was created to address. As XPRIZE announces the 20 finalist teams advancing to the next stage of the competition, we’ll look at what XPRIZE means to the global race to transform how we age – and, more importantly, what the competition has decided to measure.

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Versatile Extracellular Vesicles and the Role They Play in Longevity

Versatile Extracellular Vesicles and the Role They Play in Longevity

From diagnostics to drug delivery to regenerative medicine, extracellular vesicles (EVs) are the messengers of the moment, offering a promising glimpse of future applications to the biologists who study them and the longevity experts interested in their powerful signaling properties. No EV-based therapeutic product has yet been formally approved for marketing, but clinical evidence is building around possible applications for EVs in the future – and their implications for longevity and regenerative medicine.

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