Inflammaging is an interior perfect storm where immune system remodeling, cellular aging, or senescence, and loss of control over systemic inflammation trigger chronic overstimulation of the innate immune system. As humans age and the immune system declines, immune responses become overactive and less precise, producing pro-inflammatory cytokines that drive inflammaging and maintain a persistent low-grade inflammation that contributes to age-related diseases and functional decline.
For some humans, this is an acceptable situation, and they’ve got the rocking chairs set up on the porch, ready to fade into their declining years riddled with aches, pains, and chronic system failure. For the rest of us, science is constantly opening new doors that lead to a better understanding of inflammaging, and how to counter or even avoid it.
