Destigmatizing Hormone Replacement Therapy, Improving Women’s Health

An evolution in menopausal hormone therapy (MHT) is officially underway. New interpretations of safety data from randomized trials and observational studies have resulted in the Food and Drug Administration (FDA)’s decision to remove the class-wide black box warnings for many systemic estrogen and combined estrogen-progestogen (EPT) products, and experts in women’s health are advocating to remove the barriers and improve access to MHT.

Life-Changing Medication

Throughout the human body, hormones support physical, mental, and metabolic health. As hormone levels decline with age, the risk of arthritis, heart disease, cancer, diabetes, and other chronic conditions rises, and many women experience the symptoms of menopause and perimenopause, including hot flashes, insomnia, and brain fog. HRT provides women with bioidentical estrogen and sometimes progesterone, but a controversial Women’s Health Initiative study in 2002 suggested that the therapies raise the risk of breast cancer, putting an end to HRT’s widespread use in the U.S.

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2026: The Year of Cognitive Longevity

Human beings have been chasing longevity since the days of Herodotus in ancient Greece. What’s changed since then is that living longer is now a reality, driven by a combination of modern medicine, biotechnology, science, and public health. Today’s advances in cardiovascular care, oncology, infectious disease, and metabolic management would have astonished the ancient Greek philosopher known as the Father of History, who chronicled tales of a “fountain of youth” in 450 BCE, and the extended lifespans we enjoy today — 86.5 is the average in top-rated Monaco, 79.5 in the US — would have been unimaginable.

Modern longevity experts want more. Advances in cardiovascular prevention, cancer therapy, infectious disease control, and metabolic management have dramatically reduced early mortality and extended lifespan across populations, but the concept of cognitive longevity is increasingly being added to the human wish list. Not only do humans want to live longer, but we want to do so without the progressive cognitive decline that too often goes hand in hand with aging.

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Healthy, Holistic, and Happening Now: A Look at Longevity Trends for 2026

What does longevity look like in 2026? Experts are talking about a revolution.

Shaped by technological advancements, refined by collaborative approaches, and rooted in a growing focus on holistic methods and mental well-being, modern longevity treatments have shifted to become preventative, proactive, and personalized.

“If you think about aging more like a degenerative disease, almost like a boat with a hole in it, you don’t want to wait until the boat is filled with water to start bucketing it out,” said Jordan R. Plews, PhD, a biochemical engineer and stem cell researcher who is CEO of ELEVAI Skincare. “We need to be proactive.”

Speaking at Genesis: Innovations in Aesthetic Regenerative Medicine on December 7 in New York City, Dr. Plews noted the movement toward natural regenerative therapies like peptides and exosomes, as longevity professionals incorporate cutting-edge breakthroughs in technology in new, holistic ways.

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