Tag Archives: anti-aging

A Look into Senolytic Therapies for Longevity

With a focus on extending and improving the human lifespan, the medical community continues to explore potential avenues in longevity. One such development has directed increased attention to the practice of senolytics – or, the process of flushing senescent cells from the body to discard harmful proteins. Senescent cells are malfunctioning, aged cells which can trigger inflammation and dysfunction, developed in response to disease, injury, or cancerous formations. 

These cells can remain in the body, contributing to the development of many diseases and features of aging, such as heart disease, dementia, osteoporosis, and lung disease. Removing senescent cells from mice was found to alleviate insulin resistance, cell dysfunction, and ameliorate other complications in cases of kidney failure and disease.

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Healthy Aging Myths: Physical Deterioration and Impairment are Inevitable

As a result of incredible technological and scientific advances, human life expectancy has now doubled. According to data from the World Health Organization, the proportion of the world’s population over the age of 60 is expected to double from 11% to around 22% by the year 2050. With an increasing aging population at hand, it is important for healthcare professionals to combat the many medical myths surrounding the biological aging process which may detrimentally affect patient longevity and well-being.

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Reversing the Biological Clock

While the current increasingly aging population and enhanced human lifespan are signs of great advancement in medical technology, population aging also contributes to a variety of socioeconomic, environmental, and healthcare-related difficulties, significantly straining the global economy and healthcare system. The medical community began investigating potential biomedical strategies of reversing the aging process several years ago in the hopes of diminishing cognitive decline, weakening of the immune system, and other negative effects of biological aging. In doing so, researchers have made significant discoveries in the field, one of which now provides a definitive basis of measurement for determining biological age – the epigenetic clock.

Developed by Dr. Steve Horvath, professor of Human Genetics and Biostatistics at UCLA, the epigenetic clock utilizes the body’s epigenome and specifically, changes in DNA methylation state to determine a person’s biological age, which may often exceed or fall behind their chronological age. Dr. Horvath’s discovery has helped to elucidate novel aspects of the aging process and deepen our current understanding, promoting further research efforts aimed at uncovering the complexities of reversing systemic aging. Thus far, attempts at the reversal of biological aging have not been confirmed by epigenetic age changes although the latest trial results from California implicate the potential to effectively reverse the aging process for the first time.

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