August 11, 2022
Breakthroughs in medicine and technology account for a global increase in life expectancy, yet improvements in quality of life for the elderly population lag far behind. Human longevity coupled with poor healthspan expectations is a significant challenge facing anti-aging medicine and the future of population health. Targeted therapeutic interventions and preventive care protocols are necessary to mitigate the sharp rise in age-related disease and disability accompanying longer life expectancy.
Different designer diamines, lab-derived amines with two amino groups, are increasingly being studied for their potential to enhance the healthspan by promoting mitophagy and protecting cells against oxidative damage. In a recent study, researchers from the Hebrew University of Jerusalem evaluated a new molecule for its potential to prevent age-related diseases and increase life expectancy and wellness. Their findings were published in Autophagy and outline the role of mitophagy in age-related disease and the promising protective effect of diamines.
June 24, 2022
With deep sadness, we share the news of respected integrative cardiologist and former member of the A4M Board of Scientific Advisors, Dr. Stephen Sinatra’s passing. Dr. Sinatra was one of the most highly regarded and sought-after cardiologists whose whole-person approach to cardiovascular care revitalized patients with even the most advanced forms of disease.
A board-certified cardiologist specializing in integrative medicine, Dr. Sinatra was also certified as a bioenergetic psychotherapist and nutrition and anti-aging specialist – making his education and expertise genuinely unparalleled.
During the course of over 40 years of clinical practice, research, and study, Dr. Sinatra obtained numerous certifications, published a dozen best-selling books, and helped discover and develop healing strategies that guide integrative and anti-aging practices today.
July 16, 2021
With a focus on extending and improving the human lifespan, the medical community continues to explore potential avenues in longevity. One such development has directed increased attention to the practice of senolytics – or, the process of flushing senescent cells from the body to discard harmful proteins. Senescent cells are malfunctioning, aged cells which can trigger inflammation and dysfunction, developed in response to disease, injury, or cancerous formations.
These cells can remain in the body, contributing to the development of many diseases and features of aging, such as heart disease, dementia, osteoporosis, and lung disease. Removing senescent cells from mice was found to alleviate insulin resistance, cell dysfunction, and ameliorate other complications in cases of kidney failure and disease.