Tag Archives: menopause

Making the Most of Menopause: Aging and Autoimmunity in Women

The relationship between menopause and autoimmune disease is a women’s health issue that can no longer be ignored. Autoimmune diseases affect women far more often than men, with women accounting for approximately 80% of cases. Hormonal fluctuations during perimenopause and menopause — particularly declining estrogen levels — are associated with an increase in certain immune cells and antibodies that may worsen or contribute to disease onset.

Rheumatoid arthritis, lupus, Sjögren’s syndrome, and psoriatic arthritis are among the autoimmune conditions linked to menopause. Declining estrogen levels during this transition can increase inflammation and reduce the effectiveness of immune regulation. Although hormone therapy use in postmenopausal women has been associated with a higher incidence of certain autoimmune conditions, it has also emerged as an important tool for symptom management and improving quality of life when appropriately monitored.

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Destigmatizing Hormone Replacement Therapy, Improving Women’s Health

An evolution in menopausal hormone therapy (MHT) is officially underway. New interpretations of safety data from randomized trials and observational studies have resulted in the Food and Drug Administration (FDA)’s decision to remove the class-wide black box warnings for many systemic estrogen and combined estrogen-progestogen (EPT) products, and experts in women’s health are advocating to remove the barriers and improve access to MHT.

Life-Changing Medication

Throughout the human body, hormones support physical, mental, and metabolic health. As hormone levels decline with age, the risk of arthritis, heart disease, cancer, diabetes, and other chronic conditions rises, and many women experience the symptoms of menopause and perimenopause, including hot flashes, insomnia, and brain fog. HRT provides women with bioidentical estrogen and sometimes progesterone, but a controversial Women’s Health Initiative study in 2002 suggested that the therapies raise the risk of breast cancer, putting an end to HRT’s widespread use in the U.S.

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Featured Sessions and Perspectives from The A4M Women’s Health Summit

The energy from the sold-out 2025 Women’s Health Summit in Scottsdale continues to reverberate. Between October 9-11, practitioners gathered at The Westin Kierland for an intensive deep-dive into menopause medicine, emerging from three days armed with protocols, data, and strategies that directly address the most pressing challenge in women’s healthspan optimization: menopause. 

Our second-ever Summit delivered on its promise to equip providers to empower their patients’ journeys through this consequential and long-lasting hormonal transition. A lineup of leading female health experts presented evidence-based frameworks spanning metabolic health, hormone optimization, genetic influences, musculoskeletal preservation, mental health support, and systemic healthcare reform. Each session provided immediately applicable clinical tools designed to elevate women’s health outcomes in practice.

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