Tag Archives: epigenetics

The Androgen Clock: Decoding Epigenetic Evidence Of Hormone History

Biological history encoded within DNA reveals crucial information about health trajectories, aging patterns, and disease risks. For decades, healthcare providers have relied on hormone testing methods that capture mere snapshots – transient measurements failing to reflect lifelong hormone interactions. As a result of this fundamental limitation, our understanding and treatment of hormone-related conditions affecting millions worldwide has remained profoundly incomplete, missing critical patterns of cumulative exposure that drive disease progression and accelerate aging processes.

Enter the androgen clock – a groundbreaking diagnostic innovation analyzing DNA methylation to establish comprehensive, long-term records of androgen exposure.

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The top 5 most cited takeaways from LongevityFest 2023

5 Most-Cited Takeaways From LongevityFest 2023

Settling into the new year is the perfect time to focus on renewal, renewing our commitment to delivering excellent care and patient outcomes, and leveraging every beneficial tool at our disposal. What better way to kick off 2024 than by highlighting key learnings around longevity, healthy aging, and improving our healthspans presented at 2023’s biggest anti-aging medicine event.

Throughout the four days of LongevityFest 2023, more than 120 acclaimed experts delivered upwards of 200 forward-thinking, thought-provoking, and, beyond all, practically relevant educational sessions.

The agenda was an unforgettable learning extravaganza for longevity science and anti-aging medicine enthusiasts. From delving into the exclusive insights of Blue Zone pioneer Dan Buettner to learning about insulin-like growth factor 1 and other vital components of healthy aging, thousands of dedicated health professionals in attendance were enriched with the latest knowledge and developments in the field.

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Reversing the Biological Clock

While the current increasingly aging population and enhanced human lifespan are signs of great advancement in medical technology, population aging also contributes to a variety of socioeconomic, environmental, and healthcare-related difficulties, significantly straining the global economy and healthcare system. The medical community began investigating potential biomedical strategies of reversing the aging process several years ago in the hopes of diminishing cognitive decline, weakening of the immune system, and other negative effects of biological aging. In doing so, researchers have made significant discoveries in the field, one of which now provides a definitive basis of measurement for determining biological age – the epigenetic clock.

Developed by Dr. Steve Horvath, professor of Human Genetics and Biostatistics at UCLA, the epigenetic clock utilizes the body’s epigenome and specifically, changes in DNA methylation state to determine a person’s biological age, which may often exceed or fall behind their chronological age. Dr. Horvath’s discovery has helped to elucidate novel aspects of the aging process and deepen our current understanding, promoting further research efforts aimed at uncovering the complexities of reversing systemic aging. Thus far, attempts at the reversal of biological aging have not been confirmed by epigenetic age changes although the latest trial results from California implicate the potential to effectively reverse the aging process for the first time.

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