August 11, 2022
Breakthroughs in medicine and technology account for a global increase in life expectancy, yet improvements in quality of life for the elderly population lag far behind. Human longevity coupled with poor healthspan expectations is a significant challenge facing anti-aging medicine and the future of population health. Targeted therapeutic interventions and preventive care protocols are necessary to mitigate the sharp rise in age-related disease and disability accompanying longer life expectancy.
Different designer diamines, lab-derived amines with two amino groups, are increasingly being studied for their potential to enhance the healthspan by promoting mitophagy and protecting cells against oxidative damage. In a recent study, researchers from the Hebrew University of Jerusalem evaluated a new molecule for its potential to prevent age-related diseases and increase life expectancy and wellness. Their findings were published in Autophagy and outline the role of mitophagy in age-related disease and the promising protective effect of diamines.
October 29, 2021
One of the primary limitations of stem cell treatment and the subject of ongoing research is the challenge of directing stem cells to their necessary destination in the body which has been a subject of ongoing research. Prior studies have discovered that stem cells are drawn to inflammation in the body, however, using this as a therapeutic lure still poses risks. Thus, researchers continue their search for tools that would aid stem cells in their migration and conversion into specific types of cells necessary for optimal treatment. The ability to do so would have a wide range of implications for regenerative medicine as well as the treatment of disorders in which inflammatory signals fade over time, such as chronic spinal cord injury, stroke, or conditions in which the role of inflammation remains unknown. Continue reading
July 16, 2021
With a focus on extending and improving the human lifespan, the medical community continues to explore potential avenues in longevity. One such development has directed increased attention to the practice of senolytics – or, the process of flushing senescent cells from the body to discard harmful proteins. Senescent cells are malfunctioning, aged cells which can trigger inflammation and dysfunction, developed in response to disease, injury, or cancerous formations.
These cells can remain in the body, contributing to the development of many diseases and features of aging, such as heart disease, dementia, osteoporosis, and lung disease. Removing senescent cells from mice was found to alleviate insulin resistance, cell dysfunction, and ameliorate other complications in cases of kidney failure and disease.