Breakthroughs in medicine and technology account for a global increase in life expectancy, yet improvements in quality of life for the elderly population lag far behind. Human longevity coupled with poor healthspan expectations is a significant challenge facing anti-aging medicine and the future of population health. Targeted therapeutic interventions and preventive care protocols are necessary to mitigate the sharp rise in age-related disease and disability accompanying longer life expectancy.
Different designer diamines, lab-derived amines with two amino groups, are increasingly being studied for their potential to enhance the healthspan by promoting mitophagy and protecting cells against oxidative damage. In a recent study, researchers from the Hebrew University of Jerusalem evaluated a new molecule for its potential to prevent age-related diseases and increase life expectancy and wellness. Their findings were published in Autophagy and outline the role of mitophagy in age-related disease and the promising protective effect of diamines.