Author Archives: Zuzanna Walter

A4M Longevity Watchlist: Defining Advances And Trends Worth Your Attention 

April 6, 2025

In 2025, longevity medicine is no longer a future promise; it’s a present-day imperative. Research that once lived in academic journals is now moving into clinics, fueled by unprecedented capital investment and rapid computational advances. Discovery timelines are shrinking. Expectations are rising. And for practitioners, the choice is clear: evolve with the science or risk being left behind in a fast-specializing healthcare landscape.

Healthspan extension has evolved beyond theoretical models into evidence-based methodologies. What was once speculative is now measurable, actionable, and grounded in scientific data. Meanwhile, as conventional medicine continues to focus on treating disease, forward-thinking clinicians are shifting their attention to the root drivers of aging itself, redefining not only the aging process but also the practice of medicine.

In this seasonal update, we explore four key developments defining the longevity field right now: advances that aren’t just promising but actionable. Whether you’re a clinician, researcher, or industry leader, these breakthroughs offer both a preview of where longevity medicine is headed and a playbook for staying ahead.

Continue reading →

The Androgen Clock: Decoding Epigenetic Evidence Of Hormone History

March 22, 2025

Biological history encoded within DNA reveals crucial information about health trajectories, aging patterns, and disease risks. For decades, healthcare providers have relied on hormone testing methods that capture mere snapshots – transient measurements failing to reflect lifelong hormone interactions. As a result of this fundamental limitation, our understanding and treatment of hormone-related conditions affecting millions worldwide has remained profoundly incomplete, missing critical patterns of cumulative exposure that drive disease progression and accelerate aging processes.

Enter the androgen clock – a groundbreaking diagnostic innovation analyzing DNA methylation to establish comprehensive, long-term records of androgen exposure.

Continue reading →

International Women’s Day: Closing the Healthcare Gender Gap as a Key to Optimize Female Longevity

March 8, 2025

“The story of women’s struggle for equality belongs to no single feminist nor to any one organization but to the collective efforts of all who care about human rights.” – Gloria Steinem.

The United Nations has declared the theme for this year’s International Women’s Day as “Accelerate Action”, calling for swift action to achieve gender equality. This message rings the alarm on the slow progress being made toward this goal, as at the current rate, it will take until 2158—or approximately five generations—to reach gender parity.

The healthcare gender gap looms large. While women on average enjoy a longer life—with an additional 7 years of life expectancy compared to men—they disproportionately spend their last decade with disease, disability, and dementia, accounting for over 75% of all cases. The female longevity advantage is lost due to the time women spend in poor physical and cognitive health. This means that female lifespan advantages are not currently matched by a longer healthspan.

The concept of FemSpan, coined by Dr. Pearlman, aims to apply a female-centric approach to healthy aging and disease management to ensure that women are maximally able to benefit from their female longevity advantage with healthy aging.

Continue reading →