Category Archives: Anti-Aging Innovations

The Role of Sirtuins in Longevity

Despite strenuous controversies, the field of sirtuin research is growing with an increasing number of recent studies revealing their promising connection to longevity. After many years of investigation, understanding of the activity of the silent information regulator 2 (Sir2) family (‘sirtuins’) has greatly expanded, proving its significant involvement in the regulation of many fundamental biological processes. Dr. Leonard Guarente, co-founder of Elysium Health and director of MIT’s Glenn Center for Biology of Aging, stands at the forefront of sirtuin research efforts.

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Preventing Dementia in Patients with Mild Cognitive Impairment

According to data from the American Academy of Neurology (AAN), an estimated 6% of people worldwide suffer from mild cognitive impairment (MCI) in their 60s, and 37% are affected by age 85. Although patients with mild cognitive impairment have an increased risk of developing dementia, the condition does not always worsen and growing research aims to determine the underlying mechanisms linking the two. The progression from MCI, a slight but noticeable change in cognitive function, to dementia is not automatic; about 15% of MCI cases develop into dementia.

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The Genetics Behind Regeneration

Many animals are capable of regenerating complex body parts and restoring them to full functioning. Salamanders and planarians regrow damaged or missing body parts, while flatworms can replicate their entire bodies from minuscule components of themselves. The human body is comparatively limited in its ability to regenerate, as humans are only capable of renewing damaged organs such as the liver and skin. However, recent research in animal regeneration has revealed various stem cell strategies for regenerating body parts, that could one day be applied to humans.