Emerging research on necrosis as a therapeutic target marks a pivotal shift in the field of longevity medicine. Historically considered a passive byproduct of tissue injury, necrosis is now being recharacterized as a proactive driver of systemic aging and chronic disease.
This paradigm shift holds clinical implications across specialties, from nephrology and neurology to cardiovascular and regenerative medicine, suggesting that early intervention at the cellular death cascade could preserve organ function, limit fibrosis, and potentially delay biologic aging.
