Currently, an estimated 10 million people in the United States suffer from osteoporosis, with a disproportionate number of affected women. Caused by thyroid problems, aging, low body weight, hormonal dysfunctions, and other conventional risk factors, osteoporosis greatly increases the likelihood of fractures – especially in the spine, hip, and forearm. Fragility fractures are very common and dangerous; they not only increase morbidity and mortality rates, but they also greatly reduce mobility and quality of life.
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Benefits of HRT in Bone Health
A new cross-sectional analysis, coupled with research published last week in the Journal of Clinical Endocrinology & Metabolism, indicates that hormone-replacement therapy (HRT) can improve both bone-mineral density and bone mass/structure, with benefits that have the potential to continue up to two years after the discontinuation of treatment.
HRT is a form of therapy during which a patient receives hormones, for the purpose of supplementing a lack of naturally occurring hormones, or in order to substitute other hormones for naturally occurring hormones. Its use has been consistently studied and assessed in observational studies, case-control studies, meta-analyses, and randomized clinical trials; its applications have gradually expanded and been implemented.
Ample evidence and research further suggests that HRT is an effective first-line treatment for the prevention and treatment of osteoporosis due to its anti-fracture efficacy, primarily among young postmenopausal women—and can be continued for up to a decade. These findings are specifically significant because of the inherent downfalls of current drugs and pharmaceuticals, which have demonstrated less than optimal effects on bone microarchitecture.