The Future of Research is Female: Redressing Persistent Deficits in Women’s Health

Women’s health in the United States and across the world continues to worsen, with a widespread lack of access to healthcare and low awareness levels contributing to disparities in outcomes between men and women. Driving prevailing health inequity is a stark gap in medical research, which has been historically performed primarily on male subjects. Women have been excluded from clinical trials throughout history, limiting our understanding of female-specific health conditions and their overall health.

From cardiovascular risk factors to breast cancer and fertility, women’s health encompasses a wide range of complex issues that require specialized attention and research. Despite making up half of the global population, women are largely under-studied and underrepresented in medicine, which extends to the clinical setting. The statistics are telling: Women die at higher rates than men from heart attacks and strokes; they comprise 80 percent of all new cases of autoimmune diseases; and they are three times more likely to experience mental health disorders. The list goes on.

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What’s Next?: The 2023 Industry Trend Report for Healthcare Disruptors and Early Adopters

In 2023, the US healthcare industry is again facing several significant challenges, including ongoing high inflation rates, labor shortages, and the persistent impact of the COVID-19 pandemic. Despite continued difficulties, leaders in the space are working to find innovative solutions to improve the current system while looking ahead at the promising future of medicine that appears to have already arrived.

From artificial intelligence-based medicine to breakthroughs in precision neuroscience, we outline key trends expected to shape the healthcare landscape in 2023 and beyond.

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Canceling Menopause: Longevity Science Challenges The Reproductive Status Quo

Society has long accepted the natural decline of fertility and the onset of menopause as an inevitable part of life for women. An increased risk for age-related disease, disability, and cognitive decline, that just comes with the territory. However, the status quo of shifting hormone levels accompanied by cumbersome symptoms ranging from relatively mild (night sweats, irregular bleeding) to potentially fatal (heart disease, dementia) is now being questioned.

Humans are unique in that we are one of only five species that experience menopause and the only one that lives on land. Our closest cousins, chimpanzees, do not stop their reproductive cycles until near death. So why must we?

The truth is, there is no fundamental biological reason that requires women to begin losing the eggs essential to their future fertility before they even exit the womb. From 7 million eggs at 26 weeks of gestation down to 1 million at the time of birth, the number of eggs females carry begins to decrease exponentially, dwindling to 1,000 by age 51.

It’s worth noting that egg quality decreases with age, too: chromosomal defects increase by 0.5% each month after 35 years old, so a woman in her early 40s will likely have abnormalities in three-quarters of her remaining eggs.

While in utero and weighing approximately six large carrots (760g), a female’s fertility peaks. But does that make any evolutionary sense?

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