Category Archives: Hormone Replacement

Destigmatizing Hormone Replacement Therapy, Improving Women’s Health

An evolution in menopausal hormone therapy (MHT) is officially underway. New interpretations of safety data from randomized trials and observational studies have resulted in the Food and Drug Administration (FDA)’s decision to remove the class-wide black box warnings for many systemic estrogen and combined estrogen-progestogen (EPT) products, and experts in women’s health are advocating to remove the barriers and improve access to MHT.

Life-Changing Medication

Throughout the human body, hormones support physical, mental, and metabolic health. As hormone levels decline with age, the risk of arthritis, heart disease, cancer, diabetes, and other chronic conditions rises, and many women experience the symptoms of menopause and perimenopause, including hot flashes, insomnia, and brain fog. HRT provides women with bioidentical estrogen and sometimes progesterone, but a controversial Women’s Health Initiative study in 2002 suggested that the therapies raise the risk of breast cancer, putting an end to HRT’s widespread use in the U.S.

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The FDA Removes Its Black Box Warning on Hormone Therapy: What Does It Mean for Longevity?

After more than two decades, the U.S. Food and Drug Administration (FDA) is initiating the removal of broad “black box” warnings from hormone replacement (HRT) products for menopause. The decision to update the FDA’s position follows a comprehensive review of the scientific literature, an acknowledgement of the expert panel’s findings in July, and a public comment period.

Now, the agency is collaborating with companies to update product labeling to remove references to the risks of cardiovascular disease, breast cancer, and probable dementia, acknowledging that HRT’s risks are not uniform—they vary based on patient factors, delivery method, and formulation.

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Beyond Replacement: How BHRT Is Reshaping the Hormone Optimization Conversation

In the rapidly evolving landscape of longevity and personalized care, bioidentical hormone replacement therapy (BHRT) is no longer a fringe consideration. It’s a core tool in the age management arsenal, particularly for clinicians committed to individualized, physiology-driven medicine. As new data sharpens our understanding of hormonal health, BHRT stands at the intersection of science, aging, and quality of life.

The upcoming BHRT Symposium (September 11–13, 2025) provides a timely opportunity to reassess how we’re integrating hormone optimization into clinical care, and what it means for the future of functional and regenerative medicine.

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